Cytokine receptors associated with the JAK-family kinases phosphorylate STAT-family transcription factors (TFs), which regulate specific target genes involved in haematopoiesis and cell differentiation.

On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

Cytotherapies involving bone marrow- or adipose tissue-derived mesenchymal cells are actively pursued to treat diverse inflammatory and immunological disorders, including myocardial infarcts, osteoarthritis, autoimmune disorders, and diabetic and gastrointestinal wounds.

Transition from manual to automated processes for autologous T cell therapy manufacturing using bioreactor with expandable culture area.

While the use of adoptive T cell therapy for cancer treatment has been in research for decades, its 1st commercial product was only approved by the US Food and Drug Administration (FDA) in 2017.